The non-psychotropic plant-derived cannabinoid, CBD, has inherent anti-inflammatory, anxiolytic, anti-tumor, neuroprotective, antioxidant and anxiety-relieving properties. A proven appetite stimulant, CBD has also emerged as a weight loss aid and increases body metabolism. Animal research has shown that CBD influences weight by interacting with cannabinoid receptors in lymphoid tissue and the brain. These receptors (CB1 and CB2) are closely linked with metabolism and food consumption. Your endocannabinoid system impacts metabolism, stimulation of hunger, and weight gain besides regulation of various biological processes that are crucial to human survival.
The endocannabinoid system (ECS) is a set of specialized fatty acid-based signaling chemicals (think “keys”), its receptors (think “locks”) and the metabolic enzymes that create and disintegrates them. These endocannabinoid chemical signals work on the receptors by using the therapeutic compounds found in cannabis- cannabidiol (CBD), and 9-tetrahydrocannabinol (THC).
CBD Can Influence Metabolism Through “Fat Browning”
A newly published research in the scientific journal Molecular and Cellular Biochemistry, states the research conducted by Korean researchers on the effects of CBD administration on preadipocytes (immature fat cells) to discover its likely benefits on inhibiting obesity. Surprisingly, CBD was observed to perform the following effects:
- Trigger genes and proteins that promote the disintegration and oxidation of fat
- Raises the number and activity of mitochondria which augments the potential of the body to burn calories.
- Reduce the expression of proteins participating in lipogenesis or generation of fat cells.
These results arise jointly from the potential of CBD to induce “fat browning” – which includes the process of modifying white adipose tissue that conserves energy into brown adipose tissue that melts fat. Past research have suggested that raising brown colored fat in animals promotes glucose tolerance and safeguards against diabetes and different blood lipid abnormalities.
Ways To Avoid Metabolic Dysfunction Using CBD
Actually, over-stimulation of the endocannabinoid system, mainly through CB1 receptors stimulation, facilitates increased abdominal obesity, glucose absorption into adipocytes (fat cells), and insulin resistance in muscle tissue.
Such “metabolic dysfunction” builds up a dangerous cycle whereby additional insulin resistance in muscles and the liver heightens abdominal obesity. Furthermore, the over-activation of CB1 receptors causes greater food craving, stimulates appetite and augments body fat gain.
A different study published in 2012 evaluating the influence of various phytocannabinoids like cannabinol (CBN) and CBD on feeding behavior and patterns in rats promotes the theory that various cannabinoids regulate CB1 receptors and improves appetite and metabolism with contrasting effects.
This study observed that cannabinol (CBN) augmented food intake and body weight gain, whereas CBD reduced food intake and weight gain.
The plant compound, CBD also helped to improve a hyperactive endocannabinoid system which leads to inflammation. Its anti-inflammatory and antioxidant nature mitigates inflammation and rescues pancreatic function which protects against diabetes. CBD through the process of “browning” of fat cells converts the hard to dissolve white fat into a burnable form. In addition, researchers have found that CBD reduced the frequency of new fat cell generation and can become a potential treatment in treating obesity and diabetes management.